Coypel was an excellent tapestry designer. He designed tapestries for the Gobelins manufactory. His most successful tapestries were created from a series illustrating Don Quixote. Coypel was the first to illustrate Don Quixote in a sophisticated manner. These illustrations were painted as cartoons for tapestries, and were engraved and published in a deluxe folio in Paris in 1724.
Coypel created twenty-eight small paintings for these tapestries over a number of years. Each of the paintings was used as the centrepiece of a larger area that was richly decorated with birds, small animals, and garlands of flowers on a pattered background. Over two hundred pieces of the Don Quixote series were woven between 1714 and 1794. He received a commission to design a series of theatrical scenes for tapestries for the queen of Poland in 1747. Coypel also wrote prose, several comedies, two tragedies, and some poetry.