As well as the small number of mythological subjects which are his best known works today, he painted a wide range of religious subjects and also some portraits. He and his workshop were especially known for their Madonna and Childs, many in the round tondo shape. Botticellis best-known works are The Birth of Venus and Primavera, both in the Uffizi in Florence. He lived all his life in the same neighbourhood of Florence, with probably his only significant time elsewhere the months he spent painting in Pisa in 1474 and the Sistine Chapel in Rome in 1481–82.
Only one of his paintings is dated, though others can be dated from other records with varying degrees of certainty, and the development of his style traced with confidence. He was an independent master for all the 1470s, growing in mastery and reputation, and the 1480s were his most successful decade, when all his large mythological paintings were done, and many of his best Madonnas. By the 1490s his style became more personal and to some extent mannered, and he could be seen as moving in a direction opposite to that of a new generation of painters, creating the High Renaissance style just as Botticelli returned in some ways to the Gothic.