He also painted a few portraits, but these are more influential. A full-length Portrait of a Man in the National Gallery, London, dated 1526, seems to be the earliest Italian independent portrait at full-length, all the more unexpected as the "sitter", though clearly a wealthy nobleman, shows no sign of being from a princely ruling family. This format, and the background of an exterior largely closed off by a column the man leans on, was taken up by his main assistant Giovanni Battista Moroni, who mainly painted portraits, and was one of the most important portraitists of the mid-16th century.
He was a prominent and pious citizen of the small city of Brescia, belonging to at least two of the most prominent confraternities.